Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.

@article{Ceholski2012LethalHM,
  title={Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.},
  author={Delaine K Ceholski and Catharine A Trieber and Charles F. B. Holmes and Howard S. Young},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 32},
  pages={26596-605}
}
The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are essential components of cardiac contractility. Phospholamban modulates contractility by inhibiting SERCA, and this process is dynamically regulated by β-adrenergic stimulation and phosphorylation of phospholamban. Herein we reveal mechanistic insight into how four hereditary mutants of phospholamban, Arg(9) to Cys, Arg(9) to Leu, Arg(9) to His, and Arg(14) deletion, alter regulation of SERCA. Deletion of Arg… CONTINUE READING
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