Let us go forth and safely multiply

  title={Let us go forth and safely multiply},
  author={George M. Church},
  • G. Church
  • Published 2005
  • Engineering, Medicine
  • Nature
Synthetic biology, which involves the engineering of new biological components and organisms and the redesign of existing ones, will require community discipline and openness if it is to flourish safely, says George Church.Synthetic Biology‘Synthetic biology’ is a rapidly growing field, and this week's Nature reflects that growth. Biologists use it to test models of natural systems, as discussed by David Sprinzak and Michael B. Elowitz. Drew Endy takes the engineer's approach, seeing it as an… Expand
Engineering and ethical perspectives in synthetic biology Rigorous , robust and predictable designs , public engagement and a modern ethical framework are vital to the continued success of synthetic biology
Synthetic biology has emerged as an exciting and promising new research field, garnering significant attention from both the scientific community and the general public. This interest results from aExpand
The promise and perils of synthetic biology.
Drawing upon a set of powerful techniques for the automated synthesis of DNA molecules and their assembly into genes and microbial genomes, synthetic biology envisions the redesign of natural biological systems for greater efficiency, as well as the construction of functional "genetic circuits" and metabolic pathways for practical purposes. Expand
Building-in biosafety for synthetic biology.
The state-of-the-art in designing for biosafety is summarized and general recommendations are made (e.g. short environmental retention times) for current synthetic biology projects to better isolate themselves against potentially negative impacts. Expand
Synthetic Biology: Does Re-Writing Nature Require Re-Writing Regulation?
Technological advancements in the life sciences are continually pressing forward despite frequent and vocal resistance. Examples of such advancements include reproductive technologies, genetics, stemExpand
From “Experiments of Concern” to “Groups of Concern”: Constructing and Containing Citizens in Synthetic Biology
Synthetic biology represents a recent and explicit attempt to make biology easier to engineer, and through this to open up the design space of genetic engineering to a wider range of practitionersExpand
Synthetic biology: ethical ramifications 2009
During 2007 and 2008 synthetic biology moved from the manifesto stage to research programs. As of 2009, synthetic biology is ramifying; to ramify means to produce differentiated trajectories fromExpand
Ethical and Regulatory Challenges Posed by Synthetic Biology
The current state of affairs in the United States and Israel, ethical attitudes, and regulatory responses to synthetic biology are summarized and analyzed. Expand
Strategies for designing, testing and demonstrating safety : what synthetic biology can learn from retrospective cases
Synthetic biology is an emerging technology field within the realm of genetic engineering, differing from traditional genetic engineering in that it focuses on the modularization of genetic parts andExpand
Synthetic biology in society: learning from past experience?
  • H. Torgersen
  • Computer Science, Medicine
  • Systems and Synthetic Biology
  • 2009
Factors relevant for controversies over technologies as well as differences to the situation when modern biotechnology began to proliferate are discussed, including whether ELSI research should see its task in applying lessons from the past to ease technology introduction. Expand
Finding Hope in Synthetic Biology
  • T. Takala
  • Medicine, Political Science
  • Cambridge Quarterly of Healthcare Ethics
  • 2017
It is concluded that although the biggest promises of synthetic biology are unlikely to become reality, and the probability of accidents is fairly substantial, synthetic biology could still be seen to benefit humanity by enhancing the authors' ethical understanding and by offering a boost to world economy. Expand


Engineering a reduced Escherichia coli genome.
Techniques for precise genomic surgery were developed and applied to deleting the largest K-islands of E. coli, identified by comparative genomics as recent horizontal acquisitions to the genome, resulting in an 8.1% reduced genome size and reduction of gene count. Expand
The Singularity Is Near: When Humans Transcend Biology
A radical and optimistic view of the future course of human development from Ray Kurzweil, whom Bill Gates calls "the best person I know at predicting the future of artificial intelligence."
New Scientist magazine
  • New Scientist magazine
  • 2005
Study to explore risks, benefits of synthetic genomics http://web.mit.edu/newsoffice
  • Study to explore risks, benefits of synthetic genomics http://web.mit.edu/newsoffice
  • 2005
Synthetic Cell Projects
  • http://arep.med.harvard.edu/SBP/
  • 2004
Article | PubMed | ISI | ChemPort
  • Genome Res
  • 2002
Genome Res
  • Genome Res
  • 2002
Biohazard (Delta
  • New York,
  • 1999