Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer.

@article{Long2009Let7aMF,
  title={Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer.},
  author={Xiao-Bo Long and Guang-Bin Sun and Shuang Hu and Geng-tian Liang and Nan Wang and Xinhao Zhang and Ping-Ping Cao and Hong-tao Zhen and Yong-hua Cui and Zheng Liu},
  journal={Oncology reports},
  year={2009},
  volume={22 5},
  pages={1189-95}
}
MicroRNAs (miRNAs) are endogenously expressed non-coding RNAs, which are involved in the gene expression regulation. Lethal-7a (let-7a) is a founding member of miRNA family and recently it was found to be associated with several cancers, such as lung and colon cancers. In the present study, we found that let-7a miRNA expression was significantly downregulated both in human laryngeal squamous cancer tissues and in Hep-2 cells, a laryngeal cancer cell line, as compared with adjacent normal… CONTINUE READING

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