Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.

  title={Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts.},
  author={Allan M Gurtan and Arvind Ravi and Peter B. Rahl and Andrew D Bosson and Courtney K Jnbaptiste and Arjun Bhutkar and Charles Whittaker and Richard A. Young and Phillip A. Sharp},
  journal={Genes & development},
  volume={27 8},
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-fold to 100-fold with increases in transcription. Direct and indirect targets of this miRNA belong to a mid-gestation embryonic program that encompasses known oncofetal genes as well as oncogenes not previously… CONTINUE READING
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