Let-7 miRNA-binding site polymorphism in the KRAS 3′UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab

@inproceedings{Kjersem2012Let7MS,
  title={Let-7 miRNA-binding site polymorphism in the KRAS 3′UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab},
  author={Janne Beathe Kjersem and Tone Ikdahl and Tormod K Guren and Eva Skovlund and Halfdan Sorbye and Julian Hamfjord and Per Pfeiffer and Bengt Glimelius and Christian Kersten and Hiroko Kato Solvang and Kjell Magne Tveit and Elin H. Kure},
  booktitle={BMC Cancer},
  year={2012}
}
Recent studies have reported associations between a variant allele in a let-7 microRNA complementary site (LCS6) within the 3′untranslated region (3′UTR) of KRAS (rs61764370) and clinical outcome in metastatic colorectal cancer (mCRC) patients receiving cetuximab. The variant allele has also been associated with increased cancer risk. We aimed to reveal the incidence of the variant allele in a colorectal cancer screening population and to investigate the clinical relevance of the variant allele… CONTINUE READING

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