Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.

@article{Poulsen2013LessonsOR,
  title={Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.},
  author={Christian Poulsen and Herv{\'e} Vaucheret and Peter Brodersen},
  journal={The Plant cell},
  year={2013},
  volume={25 1},
  pages={22-37}
}
RNA silencing refers to a collection of gene regulatory mechanisms that use small RNAs for sequence specific repression. These mechanisms rely on ARGONAUTE (AGO) proteins that directly bind small RNAs and thereby constitute the central component of the RNA-induced silencing complex (RISC). AGO protein function has been probed extensively by mutational analyses, particularly in plants where large allelic series of several AGO proteins have been isolated. Structures of entire human and yeast AGO… CONTINUE READING
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