Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

  title={Lessons on Conditional Gene Targeting in Mouse Adipose Tissue},
  author={Kevin Y-S Lee and Steven J. Russell and Siegfried Ussar and J{\'e}r{\'e}mie Boucher and C{\'e}cile Vernochet and Marcelo Alves-da-Silva Mori and Graham Smyth and Michael Rourk and Carly Cederquist and Evan D Rosen and Barbara B. Kahn and C Ronald Kahn},
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS
109 Citations
52 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 109 extracted citations


Publications referenced by this paper.
Showing 1-10 of 52 references

Similar Papers

Loading similar papers…