Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

@inproceedings{Lee2013LessonsOC,
  title={Lessons on Conditional Gene Targeting in Mouse Adipose Tissue},
  author={Kevin Y-S Lee and Steven J. Russell and Siegfried Ussar and J{\'e}r{\'e}mie Boucher and C{\'e}cile Vernochet and Marcelo Alves-da-Silva Mori and Graham Smyth and Michael Rourk and Carly Cederquist and Evan D Rosen and Barbara B. Kahn and C Ronald Kahn},
  booktitle={Diabetes},
  year={2013}
}
Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. To directly compare the specificity and efficacy of different Cre lines in mediating adipocyte specific recombination, transgenic Cre lines driven by the adipocyte protein 2 (aP2) and adiponectin (Adipoq) gene promoters, as well as a tamoxifen-inducible Cre driven by the aP2 gene promoter (iaP2… CONTINUE READING
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