Lessons of ALS imaging: Pitfalls and future directions — A critical review

  title={Lessons of ALS imaging: Pitfalls and future directions — A critical review},
  author={Peter Bede and Orla Hardiman},
  booktitle={NeuroImage: Clinical},
BACKGROUND While neuroimaging in ALS has gained unprecedented momentum in recent years, little progress has been made in the development of viable diagnostic, prognostic and monitoring markers. OBJECTIVES To identify and discuss the common pitfalls in ALS imaging studies and to reflect on optimal study designs based on pioneering studies. METHODS A "PubMed"-based literature search on ALS was performed based on neuroimaging-related keywords. Study limitations were systematically reviewed and… CONTINUE READING

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