Lessons from tumor reversion for cancer treatment.

@article{Amson2013LessonsFT,
  title={Lessons from tumor reversion for cancer treatment.},
  author={Robert Amson and Judith E. Karp and Adam Telerman},
  journal={Current opinion in oncology},
  year={2013},
  volume={25 1},
  pages={59-65}
}
PURPOSE OF REVIEW Tumor reversion is the biological process by which highly tumorigenic cells lose at great extent or entirely their malignant phenotype. The purpose of our research is to understand the molecular program of tumor reversion and its clinical application. We first established biological models of reversion, which was done by deriving revertant cells from different tumors. Secondly, the molecular program that could override the malignant phenotype was assessed. Differential gene… CONTINUE READING