Lessons from tissue-specific KO of CNP/GC-B system - everlasting challenge to clinical application

Since the identification of the first natriuretic peptide, ANP, from the atrium of the heart, thirty years have passed and clinical applications have been achieved in ANP⋅BNP/GC-A system. In contrast with the distribution of the ANP⋅BNP/GC-A system as the endocrine system, the CNP/GC-B system is distributed as the paracrine/ autocrine system. \In order to… CONTINUE READING