Lessons from the study of T-cell differentiation in persistent human virus infection.

Abstract

Confusion surrounds the current classification of memory and effector T-cell subsets and there is a lack of consistency in the use of these terms between human and murine studies. The development of peptide-HLA tetrameric complexes ("tetramers") that accurately identify virus-specific T cells and can be used with a range of cell surface and intra-cellular markers has provided further insights in our understanding of the process of T-cell differentiation, or post-thymic development. We propose that T-cell differentiation subsets in human viral infection should be regarded as distinct from the current definitions of memory and effector cells; further work is needed to reveal the role of the differentiation process in anti-viral immunity.

050100150'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

479 Citations

Semantic Scholar estimates that this publication has 479 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Appay2004LessonsFT, title={Lessons from the study of T-cell differentiation in persistent human virus infection.}, author={Victor Appay and Sarah L Rowland-Jones}, journal={Seminars in immunology}, year={2004}, volume={16 3}, pages={205-12} }