Lessons from the neuropathology of atypical forms of multiple sclerosis

@article{Stadelmann2004LessonsFT,
  title={Lessons from the neuropathology of atypical forms of multiple sclerosis},
  author={Christine Stadelmann and Wolfgang Br{\"u}ck},
  journal={Neurological Sciences},
  year={2004},
  volume={25},
  pages={s319-s322}
}
Abstract.Multiple sclerosis (MS) is characterized by multiple demyelinated inflammatory lesions disseminated in the central nervous system (CNS). Additional features of MS pathology include axonal loss and gliosis. Remyelination may take place predominantly in the early stages of lesion formation. Pathologically, important inter-individual differences have been observed with respect to oligodendrocyte preservation. Furthermore, different mechanisms of demyelination, such as T-cell/macrophage… 
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References

SHOWING 1-10 OF 30 REFERENCES
Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
TLDR
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Oligodendrocytes in the early course of multiple sclerosis
TLDR
The findings indicate that the pathogenesis of demyelination may vary within different multiple sclerosis patients, and suggest that in the early course of the disease in some patients, oligodendrocytes may largely be preserved, whereas in others oligododendroglial loss is pronounced.
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
TLDR
The extent of complement activation, eosinophilic infiltration and vascular fibrosis observed in the Devic NMO cases is more prominent compared with that in prototypic multiple sclerosis, and supports a role for humoral immunity in the pathogenesis of NMO.
Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.
TLDR
The findings support the notions that there is no selective depletion of oligodendrocytes either during or shortly following central nervous system demyelination in multiple sclerosis, and that the myelin sheath is the primary target.
Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease
  • Merrill, Scolding
  • Biology, Medicine
    Neuropathology and applied neurobiology
  • 1999
TLDR
It is shown that successful therapeutic strategies for preserving the oligodendrocyte‐myelin unit must depend on knowledge of how oligodendedrocytes damage and death occurs, and one reason for this must be the limited understanding of the mechanisms underlying cell damage.
Concentric sclerosis (Baló): Morphometric and in situ hybridization study of lesions in six patients
TLDR
The findings suggest that concentric sclerosis is a variant of multiple sclerosis, that oligodendroglial loss is important in the pathogenesis of demyelination, and that partially myelinated areas probably represent stages of ongoing myelin breakdown rather than remyelinated of previously demyELinated areas.
The pathology of primary progressive multiple sclerosis.
TLDR
The present review will focus on the current knowledge of the pathology of primary progressive multiple sclerosis lesions and summarize the current findings with respect to inflammation, oligodendrocyte myelin pathology, axon destruction and immunopathology of the lesions.
Multiple sclerosis: remyelination of nascent lesions.
TLDR
The study provides new evidence that both oligodendrocytes and myelin are destroyed in new lesions, that this activity ceases completely in many lesions within a few weeks, and that remyelination frequently ensues following repopulation of the plaque by oligod endodermictes.
A quantitative analysis of oligodendrocytes in multiple sclerosis lesions. A study of 113 cases.
TLDR
The profound heterogeneity in extent and topography of OG destruction in active demyelinating lesions suggests that in subsets of multiple sclerosis patients, myelin, mature OGs and possibly OG progenitors are differentially affected.
...
1
2
3
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