Lessons from studies with genetic forms of diabetes in the mouse.

@article{Coleman1983LessonsFS,
  title={Lessons from studies with genetic forms of diabetes in the mouse.},
  author={Douglas L. Coleman},
  journal={Metabolism: clinical and experimental},
  year={1983},
  volume={32 7 Suppl 1},
  pages={162-4}
}
Genetically defined animal models of diabetes have many advantages over models in which the genetic component has not been established. Such models permit predictable numbers of normal and afflicted animals, differing by only a single gene, to be produced at will. Maintenance of these individual mutations in inbred strains of mice permits an evaluation of any gene-host interactions that act by modifying the severity of the diabetic condition. These genetic models provide precision tools for… CONTINUE READING