Lessons from senescence: Chromatin maintenance in non-proliferating cells.

@article{Rai2012LessonsFS,
  title={Lessons from senescence: Chromatin maintenance in non-proliferating cells.},
  author={Taranjit Singh Rai and Peter David Adams},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1819 3-4},
  pages={322-31}
}
Cellular senescence is an irreversible proliferation arrest, thought to contribute to tumor suppression, proper wound healing and, perhaps, tissue and organismal aging. Two classical tumor suppressors, p53 and pRB, control cell cycle arrest associated with senescence. Profound molecular changes occur in cells undergoing senescence. At the level of chromatin, for example, senescence associated heterochromatic foci (SAHF) form in some cell types. Chromatin is inherently dynamic and likely needs… CONTINUE READING