Lessons from mathematically modeling the NF-κB pathway.

  title={Lessons from mathematically modeling the NF-κB pathway.},
  author={Soumen Basak and Marcelo S Behar and Alexander Hoffmann},
  journal={Immunological reviews},
  volume={246 1},
Mathematical modeling has proved to be a critically important approach in the study of many complex networks and dynamic systems in physics, engineering, chemistry, and biology. The nuclear factor κB (NF-κB) system consists of more than 50 proteins and protein complexes and is both a highly networked and dynamic system. To date, mathematical modeling has only addressed a small fraction of the molecular species and their regulation, but when employed in conjunction with experimental analysis has… CONTINUE READING


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