Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract.

@article{Shull2000LessonsFG,
  title={Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract.},
  author={Gary E. Shull and Marian L Miller and Patrick J. Schultheis},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={278 2},
  pages={
          G185-90
        }
}
Absorption and secretion of ions in gastrointestinal and other epithelial tissues require the concerted activities of ion pumps, channels, symporters, and exchangers, which operate in coupled systems to mediate transepithelial transport. Our understanding of the identities, membrane locations, and biochemical activities of epithelial ion transporters has advanced significantly in recent years, but major gaps and uncertainties remain in our understanding of their physiological functions… CONTINUE READING

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Mouse down-regulated in adenoma (DRA) is a colonic C12/HCO3 2 exchanger and is upregulated in mice lacking the NHE3 Na1/H1 exchanger

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