Lessons from common markers of tumor-initiating cells in solid cancers

  • Olivier Gires
  • Published 2011 in Cellular and Molecular Life Sciences

Abstract

Tumor-initiating cells (TICs) have emerged as the driving force of carcinomas, which appear as hierarchically structured. TICs as opposed to the tumor bulk display tumor forming potential, which is linked to a certain degree of self-renewal and differentiation, both major features of stem cells. Markers such as CD44, CD133, CD24, EpCAM, CD166, Lgr5, CD47… (More)
DOI: 10.1007/s00018-011-0772-9

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