Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.

@article{Yoshida2004LessonsFB,
  title={Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.},
  author={Hiroyuki Yoshida and Wenjun Cheng and Jamie Hung and Denise J Montell and Erika R. Geisbrecht and Daniel Gustavo Rosen and Jinsong Liu and Honami Naora},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 21},
  pages={8144-9}
}
Dissemination of ovarian cancer is a major clinical challenge and is poorly understood at the molecular level due to a lack of suitable experimental models. During normal development of the Drosophila ovary, a dynamic process called border cell migration occurs that resembles the migratory behavior of human ovarian cancer cells. In this study, we found that myosin VI, a motor protein that regulates border cell migration, is abundantly expressed in high-grade ovarian carcinomas but not in normal… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…