Lessons from an estivating frog: sparing muscle protein despite starvation and disuse.

  title={Lessons from an estivating frog: sparing muscle protein despite starvation and disuse.},
  author={Nicholas J. Hudson and Sigrid A. Lehnert and Aaron Ingham and Beth L. Symonds and Craig E. Franklin and Gregory s. Harper},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={290 3},
  • N. HudsonS. Lehnert G. Harper
  • Published 1 March 2006
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Long (6- to 9-mo) bouts of estivation in green-striped burrowing frogs lead to 28% atrophy of cruralis oxidative fibers (P < 0.05) and some impairment of in vitro gastrocnemius endurance (P < 0.05) but no significant deficit in maximal twitch force production. These data suggest the preferential atrophy of oxidative fibers at a rate slower than, but comparable to, laboratory disuse models. We tested the hypothesis that the frog limits atrophy by modulating oxidative stress. We assayed various… 

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