Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations.


Stereospecifically labelled precursors were subjected to conversion by seven bacterial sesquiterpene cyclases to investigate the stereochemistry of their initial 1,10-cyclisation-1,3-hydride shift cascades. Enzymes with products of known absolute configuration showed a coherent stereochemical course, except for (-)-α-amorphene synthase, for which the… (More)
DOI: 10.1002/anie.201608042


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