Lessons for management of anaphylaxis from a study of fatal reactions

  title={Lessons for management of anaphylaxis from a study of fatal reactions},
  journal={Clinical \& Experimental Allergy},
  • Pumphrey
  • Published 1 August 2000
  • Medicine
  • Clinical & Experimental Allergy
The unpredictability of anaphylactic reactions and the need for immediate, often improvised treatment will make controlled trials impracticable; other means must therefore be used to determine optimal management. 

Evaluation of anaphylaxis: A simplified approach

A detailed yet simplified approach to anaphylaxis, its diagnosis, and management is given.

Anaphylaxis in practice

The clinical symptoms of anaphylaxis are identified and the necessary skills and equipment required to manage this life-threatening condition are described.

Managing anaphylaxis in general practice

Anaphylaxis is a severe, rapid and frightening allergic reaction that requires immediate treatment and how and when to respond and what follow-up to give is explained.

Adrenaline for the treatment of anaphylaxis: cochrane systematic review

This poster explains the rationale behind the decision to recommend adrenaline as the initial treatment of choice for anaphylaxis in patients with a history of an allergic reaction.

Anaphylaxis to foods

  • G. Roberts
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2007
Three crucial areas of the management of anaphylaxis due to food allgery are discussed: making a diagnosis, deciding who needs a self‐injectable adrenaline device and spotting the novel allgern.

Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registry

Primary prevention measures are recommended for patients with a history of anaphylaxis to prevent or attenuate the next reaction.

Anaphylaxis: mechanisms and management

  • J. K. LeeP. Vadas
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2011
This current review of the literature is intended for clinicians, trainees, and researchers as a comprehensive review of anaphylaxis with a focus on incorporating the latest advances in the field.

Anaphylaxis: symptoms, signs and management

Anaphylaxis is a severe and life-threatening hypersensitivity reaction and it is vital that ambulance clinicians can recognize the signs and symptoms of this serious reaction.

Treatment of a simulated child with anaphylaxis: An in situ two‐arm study

This study aims to determine whether junior medical staff correctly identify and treat paediatric anaphylaxis and whether the presence or absence of hypotension influenced the treatment, using a

Perioperative anaphylaxis in children: Etiology, time sequence, and patterns of clinical reactivity

  • E. KhalevaAmber M Franz G. du Toit
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2019
Perioperative anaphylaxis (PA) in children is an uncommon but potentially life‐threatening complication associated with anesthesia. Early identification and management of PA is essential to optimize



The clinical spectrum of anaphylaxis in north‐west England

  • R. PumphreyS. Stanworth
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1996
The clinical spectrum of anaphylaxis is assessed with a view to developing management guidelines and as a foundation for an epidemiological study.

Is unrecognized anaphylaxis a cause of sudden unexpected death?

Background: Serum tryptase levels reflect mast cell activation and correlate with anaphylactic reactions. Elevated post‐mortem serum tryptase levels have been found in witnessed fatal anaphylaxis.

Therapeutic controversies in the management of acute anaphylaxis.

  • A. F. Brown
  • Medicine
    Journal of accident & emergency medicine
  • 1998
The role, route of delivery, dose, concentration, and efficacy of the various drugs used in anaphylaxis, including Adrenaline, steroids, antihistamines, fluids, glucagon, aminophylline, and discharge drugs will be discussed in detail.

Emergency medical treatment of anaphylactic reactions. Project Team of the Resuscitation Council (UK)

This document provides a broad consensus on the appropriate emergency management of acute anaphylactic reactions by first medical responders who are unlikely to have specialised knowledge.

"Not so immediate" hypersensitivity--the danger of biphasic anaphylactic reactions.

Retrospective review of case notes of 34 patients admitted for observation after an anaphylactic reaction that had required treatment with adrenaline confirms that all patients being discharged after treatment for an acute anaphlyactic reaction must be made aware of the risk of a second phase response after apparent clinical resolution.

Postmortem findings after fatal anaphylactic reactions

In many cases of fatal anaphylaxis no specific macroscopic findings are present at postmortem examination, which reflects the rapidity and mode of death, which is often the result of shock rather than asphyxia.

Diagnosis and pathogenesis of the anaphylactic and anaphylactoid reactions to anaesthetics.

The recent progress in the identification of drug epitopes by Sepharose-solid drug phase IgE radioimmunoassay has to be reconsidered as non-specific binding of hydrophobic drugs such as propofol tohydrophobic serum IgE has been observed recently in patients with drug allergy.

Systemic mastocytosis presenting as profound cardiovascular collapse during anaesthesia

A case report of a patient with mastocytosis who suffered cardiac arrest during anaesthesia and anaphylactoid/anaphylactic shock may be delayed and lack supporting signs of histamine release such as cutaneous flushing and bronchospasm.