Lessons Learned From the First Quadruple Extremity Transplantation in the World

@article{Nasir2014LessonsLF,
  title={Lessons Learned From the First Quadruple Extremity Transplantation in the World},
  author={Serdar Nasir and Yusuf Alper Kilic and Mehmet Veli Karaaltin and Yunus Erdem},
  journal={Annals of Plastic Surgery},
  year={2014},
  volume={73},
  pages={336–340}
}
BackgroundLimb transplantation is emerging as a promising area of surgery and is an indispensable alternative for prosthetic rehabilitation of amputees, the severity of which is increasing because of combat-related injuries. Successful unilateral and bilateral limb transplantations have already been performed before this operation. MethodsWe performed the first ever quadruple limb transplantation in February 2012. The limbs procured from a 40-year-old man heart-beating donor were transplanted… 
Discussion of Lessons Learned From the First Quadruple Extremity Transplantation in the World: Comments and Concerns Regarding Quadruple Extremity Allotransplantation
TLDR
The world’s first attempt at quadruple limb allotransplantation, which unfortunately ended with a mortality on postoperative day 4, presents a case from which knowledge will be gained, questions will be raised, and future research will be directed.
Trans-femoral lower limb transplantation in a Sri Lankan patient: a case report and surgical technique
TLDR
A 52 year old male donor who became brain dead following spontaneous intra-cerebral haemorrhage became available on 24 July 2017 and both the donor and the recipient were of Blood group O.
Lower Extremity Allotransplantation: Are We Ready for Prime Time?
TLDR
A classification system of lower extremity allotransplantation is proposed based on the extent of preservation of recipient muscular innervation and detail a practical next recipient to achieve similarly positive results to those seen in hand and face allotrans transplantation.
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model
TLDR
The authors demonstrated the feasibility and superiority of ex vivo hypothermic oxygenated machine perfusion for preservation of amputated limbs over conventional static cold storage and herewith a substantial extension of the allowable ischemia time for replantation after traumatic amputation.
Is Lower Extremity Transplantation a Superior Alternative to Prostheses? No—At Least Not Yet
TLDR
Lower extremity VCA is far from being a superior alternative to advanced or even traditional prostheses and the transplant community should focus on upper extremity transplantation and revisit this topic as further advances in the field are made.
Lower Extremity Transplantation: Concepts, Challenges, and Controversies
TLDR
Reconstructive transplantation with vascularized composite allografts is an emerging frontier, with more than 200 procedures performed worldwide over the past decade, but broader feasibility will be realized only if perioperative and immunosuppressive complications are minimized and long-distance neurodegeneration is optimized.
Two Decades of Hand Transplantation
TLDR
This study found that hand transplantation provides significant restoration of function and form, especially for proximal transplants, and reduction in complications can be achieved by decreasing medication cost and patient education.
Vascularised Composite Allotransplantation – Basic Science and Clinical Applications
TLDR
The aim of this review article is to give a concise overview of the clinical and basic science advances in the field of VCA, with particular relevance to the orthoplastic surgeon.
Vascularized Composite Allotransplantation—An Emerging Concept for Burn Reconstruction
TLDR
Further development and refinement of clinically relevant immunomodulatory protocols is required to achieve immunosuppression minimization and/or successful transplantation tolerance to enable long-term survival of both the VCA itself and the patient.
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