Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98.

Abstract

PURPOSE To improve prognosis in children with acute myeloid leukemia (AML) by randomized comparisons of (1) two short consolidation cycles versus the Berlin-Frankfurt-Muenster (BFM) -type biphasic 6-week consolidation and (2) the prophylactic administration of granulocyte colony-stimulating factor (G-CSF) versus no G-CSF. Further, therapy for standard risk… (More)

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@article{Creutzig2006LessTB, title={Less toxicity by optimizing chemotherapy, but not by addition of granulocyte colony-stimulating factor in children and adolescents with acute myeloid leukemia: results of AML-BFM 98.}, author={Ursula Creutzig and Martin Zimmermann and Thomas Lehrnbecher and Norbert Graf and Johann Hermann and Charlotte Marie Niemeyer and A. Reiter and J{\"o}rg Ritter and Michael Dworzak and Jan Star{\'y} and Dirk Reinhardt}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2006}, volume={24 27}, pages={4499-506} }