Less skin irritation from alcohol‐based disinfectant than from detergent used for hand disinfection

  title={Less skin irritation from alcohol‐based disinfectant than from detergent used for hand disinfection},
  author={Line Kynemund Pedersen and Elisabeth Held and Jeanne Duus Johansen and Tove Agner},
  journal={British Journal of Dermatology},
Background  The benefit of alcohol‐based disinfectant used on normal skin has been debated. 
How irritant are n‐propanol and isopropanol? – A systematic review
The use of alcoholic‐based hand rubs (ABHRs) is an important tool for hand hygiene, especially in times of the COVID‐19 pandemic. Possible irritant effects of ABHR may prevent their use by persons at
Occupational contact allergy to sodium cocoamphopropionate in a hand cleanser
Keywords: aminoethylethanolamine; amphoacetates; disodium cocoamphodipropionate; occupational dermatitis; sodium cocoamphoacetate; sodium lauroamphoacetate; surfactant
Nurses’ perceptions of the benefits and adverse effects of hand disinfection: alcohol‐based hand rubs vs. hygienic handwashing: a multicentre questionnaire study with additional patch testing by the German Contact Dermatitis Research Group
A large number of nurses have a high risk of developing hand eczema due to hand disinfection procedures, and these procedures should be considered as a potential source of infection for nurses.
Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin
Alcohol‐based hand rub (ABHR) is widely used for hand disinfection in the health care sector. ABHR is, however, known to cause discomfort when applied on damaged skin emphasizing the unmet need for
Assessment of hand hygiene strategies on skin barrier function during COVID‐19 pandemic: A randomized clinical trial
Coronavirus disease 2019 (COVID‐19) has increased the frequency of handwashing. There is scarce evidence regarding the impact of different hand hygiene procedures on skin barrier function in clinical
Barrier damaging effects of n‐propanol in occlusion‐modified tandem repeated irritation test: Modulation by exposure factors and atopic skin disease
Recent studies provide evidence for significant and previously underestimated barrier damaging effects of repeated exposure to 60% n‐propanol in healthy skin in vivo.
Use of antiseptic hand rubs in the health and community services industry: an Australian population‐based survey
The use of antiseptic hand rubs is considered to be the gold standard for reducing the frequency of nosocomial infections, as well as being less damaging to the hands than washing with soap and water, but little is known at a population level about usage patterns.
Evaluation of antibacterial properties of various hand sanitizers wipes used for cosmetic and hand hygiene purposes in Nigeria
EDN ® inhibited all the microorganisms tested with highest and least zones of inhibition against Staphylococcus aureus and Enterococcus faecalis, respectively.
Exposures related to hand eczema: a study of healthcare workers
Targeted interventions and vocational guidance based on documented exposures and risk factors are needed to address hand eczema in healthcare workers.
Effects of disinfectants and detergents on skin irritation
The study shows that there is no summation of irritating effects of a common detergent and propanol and that the combination of washing and disinfection has a rather protective aspect compared with washing alone.


Short‐term effects of alcohol‐based disinfectant and detergent on skin irritation
Hand disinfection with alcohol‐based disinfectant or alternate use of disinfectant/detergent causes less skin irritation than hand infection with a detergent, and more long‐term studies are necessary before recommendations can be made.
Skin tolerance and effectiveness of two hand decontamination procedures in everyday hospital use
In everyday hospital practice, alcohol‐based disinfectant is more effective and better tolerated than non‐antiseptic soap; soap is at risk of spreading contamination; and skin comfort strongly influences the number and the quality of hand hygiene procedures.
Using Alcohol for Hand Antisepsis: Dispelling Old Myths
  • J. Boyce
  • Medicine
    Infection Control & Hospital Epidemiology
  • 2000
I have taken the unusual step of requesting an editorial from an author of the article being discussed in order to offer an opportunity to place the issues addressed herein in a larger context. A
Skin Irritation and Dryness Associated With Two Hand-Hygiene Regimens: Soap-and-Water Hand Washing Versus Hand Antisepsis With an Alcoholic Hand Gel
Hand antisepsis with an alcoholic–hand-gel regimen was well tolerated and did not result in skin irritation and dryness of nurses' hands, and newer alcoholic hand gels that are tolerated better than soap may be more acceptable to staff and may lead to improved hand-hygiene practices.
Clinical double-blind trial on the dermal tolerance and user acceptability of six alcohol-based hand disinfectants for hygienic hand disinfection.
Alcohol-based hand rubs that contain emolliants, irrespective of the type of alcohol (n- Propanol, iso-propanol or ethanol), are well tolerated and do not dry out or irritate the skin.
The soap chamber test. A new method for assessing the irritancy of soaps.
Efficacy of handrubbing with alcohol based solution versus standard handwashing with antiseptic soap: randomised clinical trial
During routine patient care handrubbing with an alcohol based solution is significantly more efficient in reducing hand contamination than handwashing with antiseptic soap.
Delayed hypersensitivity reactions following allergic and irritant inflammation.
A general down-regulation of the degree of hypersensitivity was observed at retesting and an increased retest reaction compared to controls was observed only in sites of earlier specific allergic inflammation.
Characteristics of wet work in the cleaning industry
Skin exposure to irritants was markedly different among cleaners who did the same cleaning activities, and a special effort on training and instruction should be made for this group of workers who have a low level of education.