Less label, more free: approaches in label-free quantitative mass spectrometry.

  title={Less label, more free: approaches in label-free quantitative mass spectrometry.},
  author={Karlie A. Neilson and Naveid Ahmad Ali and Sridevi Muralidharan and Mehdi Mirzaei and Michael Mariani and Garin{\'e} Assadourian and Albert Lee and Steven C. Van Sluyter and Paul A Haynes},
  volume={11 4},
In this review we examine techniques, software, and statistical analyses used in label-free quantitative proteomics studies for area under the curve and spectral counting approaches. Recent advances in the field are discussed in an order that reflects a logical workflow design. Examples of studies that follow this design are presented to highlight the requirement for statistical assessment and further experiments to validate results from label-free quantitation. Limitations of label-free… CONTINUE READING
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