Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery.


BACKGROUND Most studies on the effects of antipsychotics focus on achieving threshold levels of the drug. The speed and frequency with which drug concentrations reach threshold levels and rise and fall within the day are generally ignored. Based on prior data, we predicted that variations in the within-day kinetics of antipsychotic drug delivery would… (More)
DOI: 10.1016/j.biopsych.2008.01.010


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