Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases

@inproceedings{Malapelle2016LessFM,
  title={Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases},
  author={Umberto Malapelle and Pasquale Pisapia and Roberta Sgariglia and Elena Vigliar and Maria Biglietto and Chiara Carlomagno and Giuseppe Giuffr{\'e} and Claudio Bellevicine and Giancarlo Troncone},
  booktitle={Journal of clinical pathology},
  year={2016}
}
AIMS The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. Less information, however, is available on other components of the CRC genomic landscape, which are potential CRC prognostic/predictive markers. METHODS Following a previous validation study, ion-semiconductor next-generation sequencing (NGS) was employed to process 653 routine CRC samples by a multiplex PCR targeting 91 hotspot regions in 22 CRC significant genes. RESULTS A total of… CONTINUE READING

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