Less dialysis-induced morbidity and vascular instability with bicarbonate in dialysate.

@article{Graefe1978LessDM,
  title={Less dialysis-induced morbidity and vascular instability with bicarbonate in dialysate.},
  author={Ulrich Graefe and Jugoslav S. Milutinovich and William C. Follette and J E Vizzo and Albert L. Babb and Belding H. Scribner},
  journal={Annals of internal medicine},
  year={1978},
  volume={88 3},
  pages={332-6}
}
We devised three protocols to test the postulate that increased morbidity during high-efficiency dialysis with large-surface-area units (LS) might be due in part to the increased flux of bicarbonate out and acetate into the patient inherent is LS dialysis. The first protocol showed that with LS-acetate dialysis there was a marked fall in plasma bicarbonate and Pco2 during the first 3 to 4 h, followed by a rapid rise in bicarbonate above normal and return to control in Pco2. With LS-bicarbonate… CONTINUE READING