Less Effect of Intranasal Than Oral Hormone Therapy on Factors Associated With Venous Thrombosis Risk in Healthy Postmenopausal Women

@article{Hemelaar2006LessEO,
  title={Less Effect of Intranasal Than Oral Hormone Therapy on Factors Associated With Venous Thrombosis Risk in Healthy Postmenopausal Women},
  author={Majoie Hemelaar and Jan Rosing and Peter Kenemans and M C Thomassen and Didi D.M. Braat and Marius Jan van der Mooren},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2006},
  volume={26},
  pages={1660-1666}
}
Objective—To compare the effects of intranasal and oral administration of 17&bgr;-estradiol (E2) and norethisterone(acetate) [NET(A)] in healthy postmenopausal women on activated protein C (APC) resistance and other hemostatic parameters associated with venous thrombosis. Methods and Results—In this 2-center, randomized, double-blind, 1-year trial, 90 postmenopausal women (56.6±4.7 years of age) received daily either an intranasal spray with 175 &mgr;g/275 &mgr;g E2/NET (n=47) or 1 mg/0.5 mg… 
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Background Citations
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Results Citations
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Hemostatic markers in healthy postmenopausal women during intranasal and oral hormone therapy: a randomized trial

During intranasal E2/NET therapy, changes in the coagulatory and fibrinolytic markers were to some extent less than those observed during oral therapy.

Effects of intranasal versus oral hormone therapy on asymmetric dimethylarginine in healthy postmenopausal women: a randomized study.

Effects of nonoral estradiol-micronized progesterone or low-dose oral estradiol-drospirenone therapy on metabolic variables and markers of endothelial function in early postmenopause.

Effects of ultra-low-dose versus standard hormone therapy on fibrinolysis and thrombin generation in postmenopausal women.

Plasma fibrin clot properties in postmenopausal women: effects of hormone therapy

Estrogen plus progestogen therapy has a minor effect on plasma fibrin properties, but leads to the formation of thicker and more branched fibr in fibers, particularly during oral administration.

Effect of estrogen-progestin hormonal replacement therapy on blood coagulation and fibrinolysis in postmenopausal women.

The CEE associated with MP treatment may reduce AT levels, whereas unopposed CEE or transdermal 17beta-estradiol plus MP does not change AT, and hormonal replacement therapy may increase the risk of thrombosis in women with congenital or acquired thromBophilia.

Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review.

Activated protein C resistance among postmenopausal women using transdermal estrogens: importance of progestogen

Transdermal estrogens combined with norpregnanes may induce APC resistance and activate blood coagulation and provide a biological support to epidemiological data regarding the potential thrombogenic effects of norPregnanes.

Prevention and treatment of venous thromboembolism during HRT: current perspectives

  • H. Rott
  • Medicine, Biology
    International journal of general medicine
  • 2014
Bioidentical hormone therapy via the transdermal route seems to be the safest opportunity for hormone replacement therapy, although large trials for bioidentical hormones therapy are needed.

Effect of two oral doses of 17β‐estradiol associated with dydrogesterone on thrombin generation in healthy menopausal women: a randomized double‐blind placebo‐controlled study

The aim of the study was to compare the effect of the standard dose of 17β‐estradiol to a lower one on thrombin generation (TG).

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