Leslie Eleazer Orgel. 12 January 1927 — 27 October 2007

  title={Leslie Eleazer Orgel. 12 January 1927 — 27 October 2007},
  author={Jack D Dunitz and Gerald F. Joyce},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  pages={277 - 289}
Leslie Eleazer Orgel was a theoretical chemist and investigator of the origins of life who made deep and lasting contributions to both of these scientific areas. He was born in London, UK, on 12 January 1927, the second of three children of Simon and Deborah (Gnivisch) Orgel. His elder brother, Nevill, was born on 2 July 1922 and died on 28 December 1957. His younger sister, Delia, was born on 19 June 1933 and currently resides in Silver Spring, Maryland. Leslie Orgel died on 27 October 2007 in… Expand

Figures from this paper


Thermodynamic control of asymmetric amplification in amino acid catalysis
This work shows an alternative mechanism that gives rise to asymmetric amplification based on the equilibrium solid-liquid phase behaviour of amino acids in solution, which is robust and can operate in aqueous systems, making it an appealing proposition for explaining one of the most tantalizing examples of asymmetric amplified. Expand
Chiral selection in poly(C)-directed synthesis of oligo(G)
It is reported here that poly(C)-directed oligomerization of activated guanosine mononucleotides proceeds readily if the monomers are of the same optical handedness as the template, and is indeed far less efficient if theMonomers of the opposite handedness are involved. Expand
Ein Derivat des Cyclobutadiens
Durch Umsetzung von Tetramethyl-dichlor-cyclobuten mit Ni(CO)4 entsteht ein Nickel-Komplex der Zusammensetzung C8H12NiCl2. Sein organische Baustein ist auf Grund physikalischer Eigenschaften undExpand
Conditions for Purine Synthesis: Did Prebiotic Synthesis Occur at Low Temperatures?
The rate of polymerization of hydrogen cyanide to aminomalononitrile and the tetramer is quadratic in the total cyanide concentration, which indicates that concentration of cyanide may have been important in a plausible prebiotic purine synthesis. Expand
Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System
TNAs [(L)-alpha-threofuranosyl oligonucleotides] containing vicinally connected (3'-->2') phosphodiester bridges undergo informational base pairing in antiparallel strand orientation and are capableExpand
Electronic properties of transition-metal oxides—I: Distortions from cubic symmetry
Abstract The distortions from cubic symmetry which occur in certain transition-metal oxides, particularly those with the spinel structure, are discussed in terms of crystal (ligand) field theory. ItExpand
In vitro selection of bacteriophage Q-beta ribonucleic acid variants resistant to ethidium bromide.
Fluorescence studies show that the adapted and unadapted variants interact differently with ethidium bromide, which makes them cross-resistant to proflavine sulfate. Expand
Mechanism of Synthesis of Adenine from Hydrogen Cyanide under Possible Primitive Earth Conditions
  • J. Oró
  • Chemistry, Medicine
  • Nature
  • 1961
IT has recently been shown that adenine and the purine precursors 4-aminoimidazole-5-carboxamidine and formamidine are formed spontaneously from hydrogen cyanide in water–ammonia systems underExpand
Direct assembly of nucleoside precursors from two- and three-carbon units.
RNA world