Lesions of the dorsal tegmental nuclei disrupt control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task.

@article{Clark2013LesionsOT,
  title={Lesions of the dorsal tegmental nuclei disrupt control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task.},
  author={Benjamin J. Clark and James P Rice and Katherine G. Akers and Felicha T. Candelaria-Cook and Jeffrey S. Taube and Derek A. Hamilton},
  journal={Behavioral neuroscience},
  year={2013},
  volume={127 4},
  pages={566-81}
}
Navigation depends on a network of neural systems that accurately monitor an animal's spatial orientation in an environment. Within this navigation system are head direction (HD) cells which discharge as a function of an animal's directional heading, providing an animal with a neural compass to guide ongoing spatial behavior. Experiments were designed to test this hypothesis by damaging the dorsal tegmental nucleus (DTN), a midbrain structure that plays a critical role in the generation of the… CONTINUE READING

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