Lesions of intestinal epithelium by ingestion of bean lectins in rats.

@article{Oliveira1989LesionsOI,
  title={Lesions of intestinal epithelium by ingestion of bean lectins in rats.},
  author={Admar Costa de Oliveira and Benedicto de Campos Vidal and Valdemiro Carlos Sgarbieri},
  journal={Journal of nutritional science and vitaminology},
  year={1989},
  volume={35 4},
  pages={315-22}
}
Wistar rats were submitted to the action of active lectins from common dry beans (Phaseolus vulgaris) and from jack beans (Canavalia ensiformis, DC). Raw common bean was offered to the rats in an otherwise balanced diet to make 10% protein as the sole protein source. A single dose of 20 mg of jack bean lectin (concanavalin A) was given by gastric intubation. Half of the rats receiving raw bean died within 22 days of experiment. Histological findings showed ulceration and necrosis of the… CONTINUE READING