Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway.

@article{DELIA2006LesionsIT,
  title={Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway.},
  author={MICHAEL A. D'ELIA and Mark P Pereira and Yu Seon Chung and Wenjun Zhao and Andrew S. Chau and Teresa J Kenney and Mark C Sulavik and Todd A. Black and Eric D Brown},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 12},
  pages={4183-9}
}
An extensive study of teichoic acid biosynthesis in the model organism Bacillus subtilis has established teichoic acid polymers as essential components of the gram-positive cell wall. However, similar studies pertaining to therapeutically relevant organisms, such as Staphylococcus aureus, are scarce. In this study we have carried out a meticulous examination of the dispensability of teichoic acid biosynthetic enzymes in S. aureus. By use of an allelic replacement methodology, we examined all… CONTINUE READING
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