Lesions in ryanodine channels in smooth muscle cells exposed to oxidized low density lipoprotein.

  title={Lesions in ryanodine channels in smooth muscle cells exposed to oxidized low density lipoprotein.},
  author={Hamid Massaeli and Jose Alejandro Austria and Grant N Pierce},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={20 2},
The purpose of the present investigation was to investigate the subcellular basis responsible for the loss of vasoreactivity in atherosclerotic vessels. We have chosen to focus on the potential of oxidized low density lipoprotein (oxLDL), an important atherogenic agent, to alter sarcoplasmic reticulum (SR) structure and function. Vascular smooth muscle cells (VSMCs) were exposed for 1 to 6 days to low concentrations of minimally oxidized LDL. ATP was used to probe SR function in VSMCs. ATP can… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

A role for the sarcoplasmic reticulum in Ca 21 extrusion from rabbit inferior vena cava smooth muscle

  • MA Nazer, C. van Breemen
  • Am J Physiol
  • 1998
2 Excerpts

P2-purinoceptormediated formation of inositol phosphates and intracellular Ca 21 transients in human coronary artery smooth muscle cells

  • D Strobaek, SP Olesen, P Christophersen, S. Dissing
  • Br J Pharmacol
  • 1996

ATP raises [ Ca 2 1 ] i vi different P 2receptor subtypes in freshly isolated and cultured aortic myocytes

  • P Pacaud, Malam, G Loirand, C Desgranges
  • Am J Physiol
  • 1995

Similar Papers

Loading similar papers…