Lesions and identification of crystalline precipitates of glycoprotein IIb-IIIa antagonists in the rat kidney.

Abstract

Two glycoprotein IIb-IIIa antagonists (xemilofiban, SC-54684A, and orbofiban, SC-57099B), which are platelet aggregation inhibitors, caused crystalline precipitates in the kidney tubules of rats at high dosages. Dogs were not affected. Depending on the degree of the precipitation, which was dosage dependent, and the location, which differed somewhat between… (More)

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@article{Levin1999LesionsAI, title={Lesions and identification of crystalline precipitates of glycoprotein IIb-IIIa antagonists in the rat kidney.}, author={S. Levin and Rog{\'e}rio Friedman and Eliane Cortez and James A Hribar and M. Nicholas and Sally Schlessinger and Monique M Fouant and Naveed Ahmed Khan}, journal={Toxicologic pathology}, year={1999}, volume={27 1}, pages={38-43} }