Lesion-specific DNA-binding and repair activities of human O6-alkylguanine DNA alkyltransferase

Abstract

Binding experiments with alkyl-transfer-active and -inactive mutants of human O(6)-alkylguanine DNA alkyltransferase (AGT) show that it forms an O(6)-methylguanine (6mG)-specific complex on duplex DNA that is distinct from non-specific assemblies previously studied. Specific complexes with duplex DNA have a 2:1 stoichiometry that is formed without… (More)
DOI: 10.1093/nar/gks674

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