Lesion location and cognitive impact of cerebral small vessel disease.

  title={Lesion location and cognitive impact of cerebral small vessel disease.},
  author={J. Matthijs Biesbroek and Nick A. Weaver and Geert Jan Biessels},
  journal={Clinical science},
  volume={131 8},
Cerebral small vessel disease (SVD) is an important cause of cognitive impairment. Important MRI manifestations of SVD include white matter hyperintensities (WMH) and lacunes. This narrative review addresses the role of anatomical lesion location in the impact of SVD on cognition, integrating findings from early autopsy studies with emerging findings from recent studies with advanced image analysis techniques. Early autopsy and imaging studies of small case series indicate that single lacunar… CONTINUE READING
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