Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: Implications for the genesis of posttraumatic epilepsy

@article{Mckinney1997LesioninducedAS,
  title={Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: Implications for the genesis of posttraumatic epilepsy},
  author={R. Anne Mckinney and Dominique Debanne and Beat H. G{\"a}hwiler and Scott M. Thompson},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={990-996}
}
The delayed development of recurring seizures is a common consequence of traumatic head injury; the cause of such epilepsy is unknown. We demonstrate here that transection of the mature axons of CA3 pyramidal cells in hippocampal slice cultures leads to the formation by CA3 pyramidal cells of new axon collaterals that are immunoreactive with the growth-associated protein GAP-43. Individual CA3 cell axons had an elevated number of presynaptic boutons 14 days after the lesion, and dual… CONTINUE READING

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