Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?

@article{Marik2007LesionGI,
  title={Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity?},
  author={Christina Marik and Paul A. Felts and Jan Niklas Bauer and Hans Lassmann and Kenneth J. Smith},
  journal={Brain : a journal of neurology},
  year={2007},
  volume={130 Pt 11},
  pages={2800-15}
}
Lesions obtained early in the course of multiple sclerosis (MS) have been studied immunocytochemically, and compared with the early stages of the experimental lesion induced in rats by the intraspinal injection of lipopolysaccharide. Large hemispheric or double hemispheric sections were examined from patients who had died in the course of acute or early relapsing multiple sclerosis. In MS patients exhibiting hypoxia-like lesions [Pattern III; Lucchinetti et al. Ann Neurol (2000) 47: 707-17… CONTINUE READING
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