Lesion evolution in cerebral ischemia

  title={Lesion evolution in cerebral ischemia},
  author={Prof. Tobias Back and Thomas G Hemmen and Olaf G. Sch{\"u}ler},
  journal={Journal of Neurology},
There is sound evidence from histopathological and magnetic resonance imaging (MRI) studies that focal ischemic brain lesions tend to increase in size over time. Considerable lesion growth was observed in models of animal stroke as well as in patients presenting with hemispheric stroke. In focal cerebral ischemia, lesions predominantly enlarge early within 12 hours after onset. Ischemic injury is caused by complete necrosis in most of the affected tissue. By contrast, in global cerebral… CONTINUE READING