Lesion bypass activities of human DNA polymerase mu.

  title={Lesion bypass activities of human DNA polymerase mu.},
  author={Yanbin Zhang and Xiaohua Wu and Dongyu Guo and Olga Rechkoblit and John-Stephen Taylor and Nicholas E. Geacintov and Zhigang Wang},
  journal={The Journal of biological chemistry},
  volume={277 46},
DNA polymerase mu (Polmu) is a newly discovered member of the polymerase X family with unknown cellular function. The understanding of Polmu function should be facilitated by an understanding of its biochemical activities. By using purified human Polmu for biochemical analyses, we discovered the lesion bypass activities of this polymerase in response to several types of DNA damage. When it encountered a template 8-oxoguanine, abasic site, or 1,N(6)-ethenoadenine, purified human Polmu… CONTINUE READING


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