Lesion Explorer: A comprehensive segmentation and parcellation package to obtain regional volumetrics for subcortical hyperintensities and intracranial tissue

@article{Ramirez2011LesionEA,
  title={Lesion Explorer: A comprehensive segmentation and parcellation package to obtain regional volumetrics for subcortical hyperintensities and intracranial tissue},
  author={Joel Ramirez and Erin Gibson and Azhar Quddus and Nancy J. Lobaugh and Anthony Feinstein and Brian Levine and C. J. M. Scott and N. Levy-Cooperman and Fuqiang Gao and Sandra E. Black},
  journal={NeuroImage},
  year={2011},
  volume={54 2},
  pages={963-73}
}
Subcortical hyperintensities (SH) are a commonly observed phenomenon on MRI of the aging brain (Kertesz et al., 1988). Conflicting behavioral, cognitive and pathological associations reported in the literature underline the need to develop an intracranial volumetric analysis technique to elucidate pathophysiological origins of SH in Alzheimer's disease (AD), vascular cognitive impairment (VCI) and normal aging (De Leeuw et al., 2001; Mayer and Kier, 1991; Pantoni and Garcia, 1997; Sachdev et al… CONTINUE READING
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