Leser-Trélat sign with anaplastic ependymoma – an autopsy case


A 36-year-old Japanese male, who 7 years previously had been diagnosed as having an ependymoma in the left parietal region, had received surgery, chemotherapy and radiotherapy. He later developed a rapid growth of multiple skin lesions on his back and extremities, which coincided with a regrowth of the tumor. Postmortem examination revealed that the ependymoma showed anaplastic transformation and necrosis; however, no malignancy was observed in the extracranial organs. The skin lesions were histologically diagnosed as seborrheic keratoses. We have, therefore, diagnosed the patient as having Leser-Trélat sign associated with anaplastic ependymoma.

DOI: 10.1007/s004010050588

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@article{Hamada1996LeserTrlatSW, title={Leser-Tr{\'e}lat sign with anaplastic ependymoma – an autopsy case}, author={Yasuhiro Hamada and Toru Iwaki and Hiroshi Muratani and Shuhei Imayama and M. Fukui and Jun Tateishi}, journal={Acta Neuropathologica}, year={1996}, volume={93}, pages={97-100} }