Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain.

@article{Miana1984LeschNyhanSC,
  title={Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain.},
  author={M D Mi{\~n}ana and Manuel Portol{\'e}s and A. Jord{\'a} and Santiago Grisol{\'i}a},
  journal={Journal of neurochemistry},
  year={1984},
  volume={43 6},
  pages={
          1556-60
        }
}
Rats ingesting high doses of caffeine reproduce the self-destructive behaviour observed in the Lesch-Nyhan syndrome. This syndrome includes a deficit in hypoxanthine-guanine phosphoribosyltransferase. We have observed, however, that the activity of hypoxanthine-guanine phosphoribosyltransferase increases in direct proportion to the concentration of caffeine found in rat brain. It appears, therefore, that the caffeine model is not a true model for the Lesch-Nyhan syndrome, or alternatively, that… CONTINUE READING