Leptospirosis: a zoonotic disease of global importance.

@article{Bharti2003LeptospirosisAZ,
  title={Leptospirosis: a zoonotic disease of global importance.},
  author={Ajay R. Bharti and Jarlath E Nally and Jessica N. Ricaldi and Michael Matthias and Monica Diaz and Michael A. Lovett and Paul N. Levett and Robert H. Gilman and Michael R. Willig and Eduardo Gotuzzo and Joseph Michael Vinetz},
  journal={The Lancet. Infectious diseases},
  year={2003},
  volume={3 12},
  pages={
          757-71
        }
}
Leptospirosis
TLDR
Major progress has been made in the basic research of leptospirosis, and new insights have been made into the biology of Leptospira and the mechanisms used to adapt to host and external environments.
Clinical Diagnosis of Leptospirosis in Malaysia: Challenges and Prospects
TLDR
An attempt was made to review the current diagnostic methods including challenges faced by healthcare service providers during the diagnosis of acute cases, as well as the emerging technologies used for early and accurate diagnosis.
Leptospira as an emerging pathogen: a review of its biology, pathogenesis and host immune responses.
TLDR
This article will address the animal models of acute and chronic leptospire infections, and the recent developments in the genetic manipulation of the bacteria, which facilitate the identification of virulence factors involved in pathogenesis and the assessment of their potential values in the control and prevention ofLeptospirosis.
Leptospirosis: a worldwide resurgent zoonosis and important cause of acute renal failure and death in developing nations.
TLDR
The data indicate that in certain developing regions, such as the city of Salvador, Brazil, leptospirosis is misdiagnosed with other infectious disease such as dengue and the overall disease burden is likely underestimated partly because of the protean and nonspecific presentation.
Leptospira: Invasion, Pathogenesis and Persistence
TLDR
Future work that needs to be done in order to better understand the pathogenesis of leptospirosis is highlighted, thereby paving the way for the development of improved diagnostics and more effective vaccines.
Overview of Leptospirosis
TLDR
There is an urgent need for new diagnostic tests that are faster and able to detect the disease at an early stage and that may be performed in areas having limited laboratory capacity, allowing for the rapid initiation of treatment of the patient.
LEPTOSPIROSIS: CURRENT CHALLENGES OF AN OLD DISEASE
TLDR
The Spirochetes’ Biology Unit at Institut Pasteur, Paris, has just identified the first leptospiral virulence factor, Loa22, a protein of the OmpA family exposed on the cell surface of the bacteria, a candidate for the development of a vaccine.
Optimal treatment of leptospirosis: queries and projections.
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The epidemiology of three confirmed cases of leptospirosis that occurred in Baltimore, Maryland are reported and a hitherto unrecognized population at risk for acquiring L. interrogans is shown.
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TLDR
The effectiveness of antimicrobial therapy in treating leptospirosis has been difficult to assess because of the high variability of the disease's clinical course, although in severe cases, antibiotic therapy is effective even when treatment is delayed.
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Uveitis is a well-known late complication of systemic leptospirosis, a zoonotic disease caused by the water-borne spirochete Leptospira. Although it is one of the world's most widespread febrile
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
TLDR
The complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae is reported, consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes.
An urban outbreak of leptospirosis in Mumbai, India.
TLDR
The presence of pulmonary signs and symptoms and renal failure were significantly associated with mortality in patients presumed to be suffering from leptospirosis, and serovar Copenhageni accounted for 66 out of 66 cases admitted during the period of the outbreak.
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TLDR
This outbreak of acute undifferentiated febrile illness among Peruvian military recruits that developed after a training exercise in the high jungle rainforest of Peru was due to leptospirosis.
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TLDR
Cultures of uteri and kidneys from two pigs herds in New South Wales and Victoria (Australia) yielded five strains identified as Leptospira on morphological and cultural grounds, satisfying the criterion of a new species, Leptonospira fainei (type strain BUT 6T).
Asymptomatic infection and risk factors for leptospirosis in Nicaragua.
TLDR
Improvement in water sanitation and behavioral modifications to reduce environmental exposure may reduce the risk of leptospirosis in endemic areas of Leptospira transmission.
First isolation of Leptospira fainei serovar Hurstbridge from two human patients with Weil's syndrome.
TLDR
The Leptospira species was determined by serology, PCR and sequencing of bacterial DNA, and a role in human disease seems likely in two patients with Weil's disease from whom L. fainei was cultured.
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