Leptospirosis: An important infectious disease in North American horses

@article{Divers2019LeptospirosisAI,
  title={Leptospirosis: An important infectious disease in North American horses},
  author={Thomas J Divers and Y-F Chang and Nita L. Irby and Jackie Smith and Craig N. Carter},
  journal={Equine Veterinary Journal},
  year={2019},
  volume={51},
  pages={287–292}
}
North American horses are commonly exposed to Leptospira organisms. Leptospira Bratislava is the most common infecting serovar but this serovar has not been confirmed to cause clinical disease in North American horses. Leptospira Pomona type kennewicki is responsible for most of the clinical diseases (leptospirosis) in North American horses. Leptospirosis is most commonly associated with diseases of the placenta and fetus, the kidneys and the eyes in horses. In-utero infections in pregnant… Expand
Leptospira Seroprevalence in Bardigiano Horses in Northern Italy
TLDR
The high seroprevalence indicates that Bardigiano horses living in the investigated area are at high risk of exposure and infection by Leptospira spp. Expand
Seroprevalence of Leptospira in Racehorses and Broodmares in New Zealand
TLDR
Several management factors, such as grazing horses alternately with cattle or sheep, increasing horse age, and breeding horses, were linked to exposure to Leptospira in this group of horses, and risk factors were consistent with pasture-based exposure. Expand
Serological Survey of Leptospira Infection in Arabian Horses in Poland
TLDR
Results indicated high Leptospira seropositivity, thus, although any form of clinical leptospirosis is rare, it may be postulated that theLeptospiral exposure is widespread. Expand
New Insights on Leptospira Infections in a Canine Population from North Sardinia, Italy: A Sero-Epidemiological Study
TLDR
Sero-epidemiological studies reported the first sero-survey for leptospirosis in kennel and owned dogs from six areas of the north of Sardinia, indicating that rodents likely act as reservoir of spirochetes. Expand
Equine leptospirosis: Experimental challenge of Leptospira interrogans serovar Bratislava fails to establish infection in naïve horses.
TLDR
Differences between groups were found in CBC, differential counts and serum biochemistry panel (or profile), suggesting that leptospiral challenge triggered an inflammatory response, and it may suggest that L. interrogans serovar Bratislava is neither pathogenic nor host-adaptedserovar for horses, although these results might have varied if another strain from the same serovars had been used instead. Expand
Seroprevalence of Leptospira spp. in Colorado equids and association with clinical disease
  • A. Fagre, C. Mayo, K. Pabilonia, G. Landolt
  • Medicine
  • Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2020
TLDR
Query of specimens from clinical cases submitted to the Colorado State University Veterinary Diagnostic Laboratory for MAT indicated significantly greater seroprevalence of pathogenic serovar Pomona in clinical cases compared to sera submitted from healthy equids for routine EIA testing, which suggests a correlation between uveitis or other ophthalmic problems and serovars Pomona. Expand
Seroprevalence of Leptospira spp. in Horses in Israel
TLDR
The first identification of Leptospira serogroup Pomona as the probable cause of ERU in horses in Israel is described, followed by an epidemiological investigation of equine exposure in the area. Expand
Evidence of Leptospiral Presence in the Cumberland Gap Region
TLDR
Results from this study show exposure to leptospiral infection in farm animals and the presence of this zoonotic pathogen in the environmental water and kidneys of a significant number of small wild mammals. Expand
Detection of Anti-LipL32 Antibodies in Serum Samples from Horses with Chronic Intraocular Infection with Leptospira spp.
TLDR
Sensitivity and specificity are lower in serum samples compared to intraocular samples, however, the SNAP Lepto is far superior to MAT and suitable as a screening method using equine serum. Expand
The Leptospiral General Secretory Protein D (GspD), a secretin, elicits complement-independent bactericidal antibody against diverse Leptospira species and serovars
TLDR
The potential of General secretory protein D (GspD), a secretin, to serve as a possible antigen in a multi-valent vaccine formulation is investigated and antibody to GspD is bactericidal against diverse Leptospira species of the P1 subclade. Expand
...
1
2
...

References

SHOWING 1-10 OF 78 REFERENCES
Leptospirosis in horses.
TLDR
Prevention of equine leptospirosis must rely on good hygiene practices, minimisation of rodent contact, and vaccination of other species of production and companion animals. Expand
Acute respiratory failure caused by Leptospira spp. in 5 foals.
TLDR
5 cases of foals with respiratory distress caused by leptospirosis are described, primarily associated with recurrent uveitis, abortions, stillbirth, neonatal disease, hemolysis, renal disease, and liver disease. Expand
Experimental Leptospira interrogans serovar Kennewicki infection of horses.
TLDR
Clinical disease in experimentally infected horses can be mild or inapparent in Leptospira infected horses, and Repeated serologic testing can allow recognition of the infecting serovar. Expand
Leptospiral abortion and leptospiruria in horses from the same farm.
TLDR
Leptospirosis was documented as the cause of abortion in a 5-year-old mare and leptospires were detected by direct fluorescent-antibody testing in urine samples from the mare that aborted and from 2 of the other 5 horses on the farm. Expand
Leptospirosis in horses in Ontario.
TLDR
Serovar bratislava appears to be widespread in horses in Ontario but unimportant in abortion, and leptospires were not detected by immunofluorescence and isolation techniques in 50 kidneys collected from horses at slaughter. Expand
Acute renal disease from Leptospira interrogans in three yearlings from the same farm
TLDR
3 horses with acute renal disease from Leptospira interrogans developed an acute and persistent febrile illness that could have been attributed to a number of infectious diseases. Expand
Overview of laboratory methods to diagnose Leptospirosis and to identify and to type leptospires.
TLDR
Serological tests facilitate the detection and identification of leptospire strains, and typing is important for both epidemiologic purposes and clinical analyses, to determine which serovars circulate in the environment. Expand
Role of Intraocular Leptospira Infections in the Pathogenesis of Equine Recurrent Uveitis in the Southern United States
TLDR
Horses with ERU had a high prevalence of Leptospira infection based on PCR and MAT results from intraocular fluids compared with control horses, and should be considered as a cause of ERU in the Southern United States. Expand
Multiple specificities of immunoglobulin M in equine fetuses infected with Leptospira interrogans indicate a competent immune response.
TLDR
Although mainly mediated by IgM, a high level of immune competence in aborted fetuses was evidenced by the multiplicity of Leptospira proteins targeted, likely to contribute to survival of foals in mares with evidence of placental infection at foaling as detailed in a typical outbreak. Expand
Renal dysfunction associated with infection of Leptospira interrogans in a horse.
TLDR
Serologic testing during a 6-month period supported an acute infection with L interrogans serovar pomona in a horse, and treatment with intravenously administered fluids and antimicrobials resulted in clinical recovery. Expand
...
1
2
3
4
5
...