Leptospira immunoglobulin-like protein B (LigB) binding to the C-terminal fibrinogen αC domain inhibits fibrin clot formation, platelet adhesion and aggregation.

Abstract

Leptospira immunoglobulin-like (Lig) proteins including LigA and LigB are adhesins that bind to fibronectin, collagen, laminin and elastin. In addition, Lig proteins are fibrinogen (Fg)-binding proteins, although the physiological role of the Lig-Fg interaction is unclear. In this study, a previously identified Fg-binding region, LigBCen2 (amino acids 1014… (More)
DOI: 10.1111/j.1365-2958.2010.07510.x

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@article{Lin2011LeptospiraIP, title={Leptospira immunoglobulin-like protein B (LigB) binding to the C-terminal fibrinogen αC domain inhibits fibrin clot formation, platelet adhesion and aggregation.}, author={Yi-Pin Lin and Sean P. McDonough and Yogendra Sharma and Yung-Fu Chang}, journal={Molecular microbiology}, year={2011}, volume={79 4}, pages={1063-76} }