Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways

@inproceedings{dAndon2014LeptospiraII,
  title={Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways},
  author={Martine Fanton d'Andon and Nathalie Quellard and B{\'e}atrice Fernandez and Gwenn Ratet and Sonia Lacroix-Lamand{\'e} and Alain Vandewalle and Ivo G Boneca and J M Goujon and Catherine Werts},
  booktitle={PLoS neglected tropical diseases},
  year={2014}
}
BACKGROUND Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe leptospirosis that may lead to renal failure and fibrosis. L. interrogans provoke an interstitial nephritis, but the induction of fibrosis caused by L. interrogans has not been studied in murine… CONTINUE READING
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