Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women.

@article{Brinkoetter2011LeptinTR,
  title={Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women.},
  author={Mary T Brinkoetter and Faidon Magkos and Maria T Vamvini and Christos Socrates Mantzoros},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={301 1},
  pages={E99-E104}
}
Animal studies in vivo indicate that leptin treatment in extremely leptin-sensitive ob/ob mice reduces body weight exclusively by reducing fat mass and that it increases muscle mass by downregulating myostatin expression. Data from human trials are limited. Therefore, we aimed at characterizing the effects of leptin administration on fat mass, lean body… CONTINUE READING