Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice.

@article{Hamrick2005LeptinTI,
  title={Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice.},
  author={Mark W Hamrick and Mary Anne Della-Fera and Yang-Ho Choi and Catherine Margaret Pennington and Diane L. Hartzell and Clifton A. Baile},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2005},
  volume={20 6},
  pages={
          994-1001
        }
}
UNLABELLED Normal mice and leptin-deficient ob/ob mice were treated with leptin to study effects on osteogenesis and adipogenesis in bone marrow. Leptin treatment significantly decreased bone marrow adipocyte size and number in ob/ob mice while increasing bone formation, BMC, and BMD. The results suggest that, in leptin-sensitive animals, the reduction in marrow adipocytes has positive effects on bone formation. INTRODUCTION Adipocytes, osteoblasts, and osteoclasts have leptin receptors, and… CONTINUE READING
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